On the Regioselectivity of the Nickel-Catalyzed Insertion of Alkynes into the Carbon–Carbon Bond of Oxetan-3-one

Published as part of the Special Topic Advanced Strategies in Synthesis with Nickel

Abstract

The study of the regioselectivity of insertion of unsymmetrical alkynes into the carbon–carbon bond of oxetan-3-one in the presence of a nickel catalyst has revealed a strong directing effect of a 2-thienyl substituent. This effect is larger than those of 2-vinylbenzene, trimethylsilyl, aryl, or 3-thienyl groups.

Key words

carbon–carbon bond activation - nickel - catalysis - oxetanone - alkynes - regioselectivity - insertion - pyrans

• References


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