Facile Access to Amido (Thio)xanthates under Eco-Friendly Conditions by One-Pot Three-Component Reaction (3-CR)

Abstract

A straightforward three-component reaction (3-CR) for the preparation of a variety of biologically interesting amido (thio)xanthates has been developed. By the proper choice of a potassium (thio)xanthate salt, a cyclic or acyclic imine, and an acyl chloride as substrates a broad scope with respect to the substituents can be realized. This operationally simple one-pot method proceeds under mild and environmentally friendly conditions while potassium chloride is produced as the single waste-product.

Key words

multicomponent reactions - heterocycles - xanthates - thiocarbonates - imines - green chemistry

• References

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