Synthesis 2017; 49(18): 4163-4172
DOI: 10.1055/s-0036-1589016
special topic
© Georg Thieme Verlag Stuttgart · New York

2-(Aminomethyl)-3-arylindoles from 3-(o-Trifluoroacetamidoaryl)-1-propargylic Alcohols, Aryl Halides, and Amines: A Domino Palladium-Catalyzed Three-Component Approach

Sandro Cacchi, Giancarlo Fabrizi, Antonella Goggiamani*, Antonia Iazzetti, Rosanna Verdiglione
  • Dipartimento di Chimica e Tecnologie del Farmaco, La Sapienza, Università di Roma, P. le A. Moro 5, 00185 Rome, Italy   Email: antonella.goggiamani@uniroma1.it
Further Information

Publication History

Received: 13 March 2017

Accepted after revision: 04 April 2017

Publication Date:
28 April 2017 (eFirst)

Published as part of the Special Topic Modern Cyclization Strategies in Synthesis

Abstract

A simple, straightforward palladium-catalyzed approach to 2-(aminomethyl)-3-arylindoles from 3-(o-trifluoroacetamidoaryl)-1-propargylic alcohols, amines, and aryl iodides has been developed.

Supporting Information

 
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