Synthesis 2017; 49(17): 3945-3951
DOI: 10.1055/s-0036-1588813
special topic
© Georg Thieme Verlag Stuttgart · New York

Ethylene Glycol Assisted Intermolecular Pauson–Khand Reaction

Albert Cabré
a  Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, Barcelona 08028, Spain   Email: antoni.riera@irbbarcelona.org   Email: xavier.verdaguer@irbbarcelona.org
,
a  Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, Barcelona 08028, Spain   Email: antoni.riera@irbbarcelona.org   Email: xavier.verdaguer@irbbarcelona.org
b  Departament de Química Inorgànica i Orgànica, Secció Orgànica, Universitat de Barcelona, Martí i Franquès 1, Barcelona 08028, Spain
,
a  Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, Barcelona 08028, Spain   Email: antoni.riera@irbbarcelona.org   Email: xavier.verdaguer@irbbarcelona.org
b  Departament de Química Inorgànica i Orgànica, Secció Orgànica, Universitat de Barcelona, Martí i Franquès 1, Barcelona 08028, Spain
› Author Affiliations
Supported by: We thank the Spanish Ministerio de Economia y Competividad (CTQ2014-56361-P) and IRB Barcelona for financial support. IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from MINECO (Government of Spain). CTQ2014-56361-P
Further Information

Publication History

Received: 15 March 2017

Accepted after revision: 10 April 2017

Publication Date:
27 April 2017 (eFirst)

Published as part of the Special Topic Cobalt in Organic Synthesis

Abstract

The use of ethylene glycol as additive in the N-oxide-promoted intermolecular Pauson–Khand reaction (PKR) has been studied. The addition of 15% ethylene glycol to the reaction mixture consistently increased (from 20% up to 2–4-fold) the reaction yields.

Supporting Information

 
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