One-Step Synthesis of a Unique Molecular Platform for the Selective Functionalization of Calixarenes
Received: 24 October 2016
Accepted after revision: 01 December 2016
03 January 2017 (eFirst)
High selectivity is crucial for the functionalization of macrocyclic platforms bearing multiple identical functions. In the case of calixarenes, only a few examples of efficient homo-functionalization have been reported. Herein, we describe the one-step synthesis of a tri-differentiated calixarene and its use as a key intermediate to selectively access various homo- and hetero-functionalization patterns. In combination with the ‘all-but-one’ carbamatation methodology, this unique building block gives access to sophisticated calixarenes that, until now, were inaccessible.