Spontaneous Phospholipid Membrane Formation by Histidine Ligation
Received: 02 August 2016
Accepted after revision: 29 September 2016
19 October 2016 (eFirst)
‡ These authors contributed equally
A major challenge for the construction of artificial lipid membranes is the development of simple and robust methods for mimicking natural phospholipid membrane generation. Here we describe a nonenzymatic and chemoselective approach that relies on histidine ligation to form phospholipids de novo from water-soluble amphiphilic precursors. The resulting phospholipids can spontaneously self-assemble into micron-sized vesicles and encapsulate biomacromolecules.