Synlett 2017; 28(01): 108-112
DOI: 10.1055/s-0036-1588634
© Georg Thieme Verlag Stuttgart · New York

Spontaneous Phospholipid Membrane Formation by Histidine Ligation

Roberto J. Brea ‡, Ahanjit Bhattacharya ‡, Neal K. Devaraj*
  • Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Building: Urey Hall, Room: 4120, La Jolla, CA 92093, USA   Email:
Further Information

Publication History

Received: 02 August 2016

Accepted after revision: 29 September 2016

Publication Date:
19 October 2016 (eFirst)

These authors contributed equally


A major challenge for the construction of artificial lipid membranes is the development of simple and robust methods for mimicking natural phospholipid membrane generation. Here we describe a nonenzymatic and chemoselective approach that relies on histidine ligation to form phospholipids de novo from water-soluble amphiphilic precursors. The resulting phospholipids can spontaneously self-assemble into micron-sized vesicles and encapsulate biomacromolecules.

Supporting Information