TY - JOUR AU - Brea, Roberto J.; Bhattacharya, Ahanjit; Devaraj, Neal K. TI - Spontaneous Phospholipid Membrane Formation by Histidine Ligation SN - 0936-5214 SN - 1437-2096 PY - 2017 JO - Synlett JF - Synlett LA - EN VL - 28 IS - 01 SP - 108 EP - 112 ET - 2016/10/19 DA - 2016/12/20 KW - self-assembly KW - phospholipid KW - membrane KW - histidine ligation KW - protocell AB - A major challenge for the construction of artificial lipid membranes is the development of simple and robust methods for mimicking natural phospholipid membrane generation. Here we describe a nonenzymatic and chemoselective approach that relies on histidine ligation to form phospholipids de novo from water-soluble amphiphilic precursors. The resulting phospholipids can spontaneously self-assemble into micron-sized vesicles and encapsulate biomacromolecules. PB - © Georg Thieme Verlag DO - 10.1055/s-0036-1588634 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1588634 ER -