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Synthesis 2017; 49(19): 4434-4447
DOI: 10.1055/s-0036-1588535
DOI: 10.1055/s-0036-1588535
short review
Pd-catalyzed Auto-Tandem Cascades Based on N-Sulfonylhydrazones: Hetero- and Carbocyclization Processes
Financial support of this work by the Ministerio de Economía y Competitividad (MINECO) of Spain: Grants CTQ2013-41336-P and CTQ2016-76794-P (AEI/FEDER, UE). A Severo Ochoa predoctoral fellowship (Principado de Asturias, Spain) to R.B. is gratefully acknowledged.Weitere Informationen
Publikationsverlauf
Received: 07. Juni 2017
Accepted after revision: 12. Juli 2017
Publikationsdatum:
10. August 2017 (online)
Abstract
The Pd-catalyzed cross-coupling between N-tosylhydrazones and organic halides is a powerful method for the creation of C–C bonds. This transformation has been included recently in cascade processes in which the same catalyst promotes various independent catalytic steps, a process known as auto-tandem catalysis. This strategy proves to be very useful for the construction of relatively complex carbo- and heterocyclic structures, as well as for the generation of molecular diversity. This short review will cover the different Pd-catalyzed auto-tandem reactions involving N-tosylhydrazones organized by the bond-forming sequence: C–C/C–N and C–C/C–C. Some examples of related tandem reactions leading to acyclic compounds are also highlighted.
1 Introduction
2 Auto-Tandem C–C/C–N Bond-Forming Reactions
3 Auto-Tandem C–C/C–C Bond-Forming Reactions
4 Tandem Reactions for the Synthesis of Linear Molecules
5 Summary and Outlook
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For selected examples of C–C/C–N Pd-catalyzed auto-tandem processes, see:
For selected examples of C–N/C–C Pd-catalyzed auto-tandem processes, see:
For selected examples of C–C/C–C Pd-catalyzed auto-tandem processes, see:
For previous Pd-catalyzed cross-couplings involving the migratory insertion of Pd carbenes, see: