Synthesis 2017; 49(18): 4133-4136
DOI: 10.1055/s-0036-1588459
psp
© Georg Thieme Verlag Stuttgart · New York

Scalable Syntheses of Chirally Pure Mono-protected and Orthogonally Di-protected cis-3,4-Diaminotetrahydrofurans

Franz J. Weiberth*a, Andre J. Bourqueb, Steven Elenbaasa, Reda Hannaa, Matthew R. Powersa, Craig S. Siegela, Jin Zhaoa
  • aSynthesis Development, Sanofi U.S. R&D, 153 Second Ave, Waltham, MA 02451, USA   Email: Franz.weiberth@sanofi.com
  • bAnalytical R&D, Sanofi U.S. R&D, 153 Second Ave, Waltham, MA 02451, USA
Further Information

Publication History

Received: 03 May 2017

Accepted: 14 May 2017

Publication Date:
04 July 2017 (eFirst)

Abstract

Scalable and chromatography-free syntheses of chirally pure and orthogonally protected cis-3,4-diaminotetrahydrofurans prepared from a single starting material, 3,4-epoxytetrahydrofuran, are presented.

Supporting Information