Synthesis 2017; 49(17): 4007-4016
DOI: 10.1055/s-0036-1588429
paper
© Georg Thieme Verlag Stuttgart · New York

Transition-Metal- and Halogen-Free Oxidation of Benzylic sp3 C–H Bonds to Carbonyl Groups Using Potassium Persulfate

Yixin Hu
Department of Chemistry, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. of China   eMail: luwj@sjtu.edu.cn
,
Lihong Zhou
Department of Chemistry, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. of China   eMail: luwj@sjtu.edu.cn
,
Department of Chemistry, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. of China   eMail: luwj@sjtu.edu.cn
› Institutsangaben

We thank the National Natural Science Foundation of China (Grant No. 21372153) for financial support.
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Publikationsverlauf

Received: 17. März 2017

Accepted after revision: 28. April 2017

Publikationsdatum:
06. Juni 2017 (online)


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Abstract

Aryl carbonyl compounds including acetophenones, benzophenones, imides, and benzoic acids are prepared from benzyl substrates using potassium persulfate as oxidant with catalytic pyridine in acetonitrile under mild conditions. Neither transition metals nor halogens are involved in the reactions.

Supporting Information