Pardon the Interruption: A Modification of Fischer’s Venerable Reaction for the Synthesis of Heterocycles and Natural Products
Received: 17 November 2016
Accepted: 21 November 2016
08 December 2016 (eFirst)
‡ These authors contributed equally.
This account provides an overview of our laboratory’s studies of an unusual variant of the Fischer indolization reaction. We describe the discovery of the so-called ‘interrupted Fischer indolization’ and the development of the reaction from a methodological standpoint. In addition, our efforts to evaluate and apply this methodology in the context of akuammiline alkaloid total synthesis are discussed.
2 Interrupted Fischer Indolization Methodology
3 Applications in Akuammiline Alkaloid Total Synthesis
4 Concluding Thoughts