Synthesis 2017; 49(04): 776-789
DOI: 10.1055/s-0036-1588371
short review
© Georg Thieme Verlag Stuttgart · New York

Recent Developments in the Direct Synthesis of Unprotected Primary­ Amines

Luca Legnani
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany   Email: [email protected]
,
Benjamin N. Bhawal
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany   Email: [email protected]
,
Bill Morandi*
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 06 October 2016

Accepted after revision: 14 November 2016

Publication Date:
16 December 2016 (online)


Abstract

A large number of reports describe the formation of the fundamental C–N bond in homogeneous catalysis. Among them, only a few are able to introduce the unprotected amino group, despite the appealing insertion of this key functional group. Recently, a broad range of methods have been reported that enable direct access to the primary amine using either ammonia or other nitrogen sources. In this short review, we illustrate the progress achieved in this field.

1 Introduction

2 Hydroamination

3 Reductive Amination

4 Dehydrogenative Coupling with Alcohols

5 Amination of Aryl Halides and Boronates

6 Allylic Amination

7 C–H Amination

8 Aminofunctionalization

9 Conclusions

 
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