Synthesis 2017; 49(03): 554-556
DOI: 10.1055/s-0036-1588364
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© Georg Thieme Verlag Stuttgart · New York

A Three-Step Protocol towards N-8-(2,2-Dimethoxyethyl)-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one

Kevin Blades*
RedxAnti-infectives, Mereside, Alderley Park, Macclesfield, Cheshire, SK104TG, UK   eMail: [email protected]
,
Steven C. Glossop
RedxAnti-infectives, Mereside, Alderley Park, Macclesfield, Cheshire, SK104TG, UK   eMail: [email protected]
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Publikationsverlauf

Received: 21. Oktober 2016

Accepted after revision: 06. November 2016

Publikationsdatum:
28. November 2016 (online)


Abstract

An efficient high-yielding three-step synthesis of N-8-(2,2-dimethoxyethyl)-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one is reported. The route utilises a Heck coupling as the key step.

 
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