Synthesis 2016; 48(23): 4050-4059
DOI: 10.1055/s-0035-1562527
short review
© Georg Thieme Verlag Stuttgart · New York

External-Oxidant-Based Multicomponent Reactions

Lisa Moni
Università degli Studi di Genova, Dipartimento di Chimica e Chimica Industriale, Via Dodecaneso 31, 16146 Genova, Italy   Email: [email protected]
,
Luca Banfi
Università degli Studi di Genova, Dipartimento di Chimica e Chimica Industriale, Via Dodecaneso 31, 16146 Genova, Italy   Email: [email protected]
,
Renata Riva
Università degli Studi di Genova, Dipartimento di Chimica e Chimica Industriale, Via Dodecaneso 31, 16146 Genova, Italy   Email: [email protected]
,
Andrea Basso*
Università degli Studi di Genova, Dipartimento di Chimica e Chimica Industriale, Via Dodecaneso 31, 16146 Genova, Italy   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 21 June 2016

Accepted after revision: 02 July 2016

Publication Date:
01 September 2016 (online)


Abstract

This short review covers an innovative approach in multicomponent chemistry involving the employment of an external oxidant. This approach is exploited either to generate one of the reagents of the multicomponent reaction (MCR) or to transform one advanced intermediate into a final stable product. Both aspects are critically analyzed and examples taken from the recent literature are discussed in detail.

1 Introduction

2 Generation of One Reactant through an Oxidative Process

2.1 Passerini Reactions

2.2 Ugi-Type Reactions

2.3 Other Multicomponent Reactions

3 Oxidation of an Advanced Intermediate as a Driving Process

3.1 Aromatization of a Reaction Intermediate

3.2 Oxidation of an Advanced Intermediate without Aromatization

4 Conclusions

 
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