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Synthesis 2016; 48(17): 2829-2836
DOI: 10.1055/s-0035-1562442
special topic
© Georg Thieme Verlag Stuttgart · New York

Nickel-Catalyzed Reductive Cross-Coupling of Benzyl Halides with Aryl Halides

Qingchen Zhang
a   Center for Supramolecular Materials and Catalysis and Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, P. R. of China
,
Xuan Wang
a   Center for Supramolecular Materials and Catalysis and Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, P. R. of China
,
Qun Qian*
a   Center for Supramolecular Materials and Catalysis and Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, P. R. of China
,
Hegui Gong*
a   Center for Supramolecular Materials and Catalysis and Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, P. R. of China
b   Shanghai Key Lab of Chemical Assessment and Sustainability, Tongji University, 1239 Siping Road, Shanghai 200092, P. R. of China   Email: hegui_gong@shu.edu.cn   Email: Qianqun@shu.edu.cn
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Further Information

Publication History

Received: 26 April 2016

Accepted after revision: 06 June 2016

Publication Date:
07 July 2016 (online)

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Abstract

Systematic studies of the coupling of benzylic with aryl halides are presented. The optimized reaction conditions for electron-deficient­ aryl halides cannot be applied to the electron-rich or neutral counterparts, and vice versa. The excellent functional group tolerance and broad substrate scope may enable the current work to be useful for the construction of diaryl methane products.

Key words

nickel - cross-coupling - arylation - alkyl halide - catalysis

Supporting Information

    Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562442.
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  • References


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