Synthesis 2016; 48(12): 1920-1926
DOI: 10.1055/s-0035-1561950
special topic
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed Aerobic Oxidative Cyclization of Ketoxime Acetates with Pyridines for the Synthesis of Imidazo[1,2-a]pyridines

Zhi-Hui Ren*
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R. of China   Email: guanzhh@nwu.edu.cn
,
Mi-Na Zhao
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R. of China   Email: guanzhh@nwu.edu.cn
,
Yukun Yi
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R. of China   Email: guanzhh@nwu.edu.cn
,
Yao-Yu Wang
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R. of China   Email: guanzhh@nwu.edu.cn
,
Zheng-Hui Guan*
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R. of China   Email: guanzhh@nwu.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 24 January 2016

Accepted after revision: 23 February 2016

Publication Date:
29 March 2016 (eFirst)

Abstract

A copper(I)-catalyzed aerobic oxidative coupling of ketoxime acetates with simple pyridines for the synthesis of imidazo[1,2-a]pyridines has been developed. This reaction tolerates a wide range of functional groups and it affords a series of valuable imidazo[1,2-a]pyridines in high yields under mild conditions.

Supporting Information

 
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