Synthesis 2016; 48(17): 2732-2738
DOI: 10.1055/s-0035-1561664
short review
© Georg Thieme Verlag Stuttgart · New York

Sonogashira-Like Coupling Reactions with Phosphine–Gold(I) Alkynyl Complexes

Mogens Brøndsted Nielsen*
Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen Ø, Denmark   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 26 April 2016

Accepted: 29 April 2016

Publication Date:
16 June 2016 (online)


Abstract

Phosphine–gold(I) alkynyl complexes are stable compounds that can be subjected to palladium-catalyzed cross-coupling reactions. This article outlines the synthesis of such compounds and their ability to play the role as substrates in Sonogashira couplings is covered. This synthetic approach is particularly attractive when the related terminal alkynes are unstable.

1 Introduction

2 Phosphine–Gold(I) Alkynyl Complexes

3 Sonogashira-Like Couplings

4 Transmetalation Step – Mechanistic Insight

5 Acetylenic Scaffolding with Tetraethynylethene Derivatives

6 Conclusion

 
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