Synthesis 2016; 48(20): 3479-3503
DOI: 10.1055/s-0035-1561490
feature
© Georg Thieme Verlag Stuttgart · New York

Organocatalytic Multicomponent Reactions of 1,3-Dicarbonyls for the Synthesis of Enantioenriched Heterocycles

Haiying Du
,
Yohan Dudognon
,
Maria del Mar Sanchez Duque
,
Sébastien Goudedranche
,
Damien Bonne
,
Jean Rodriguez
,
Xavier Bugaut*
,
Thierry Constantieux*
Further Information

Publication History

Received: 13 May 2016

Accepted after revision: 01 June 2016

Publication Date:
16 August 2016 (online)

Both authors contributed equally to this study.

Abstract

In this feature article, a general perspective of the research program aimed towards the preparation of polycyclic heterocycles by the means of enantioselective organocatalytic multicomponent reactions is presented. Guidelines for reaction design, including the selection of substrates and organocatalysts are discussed. For all transformations, scope and limitations are presented, along with post-functionalization to afford diversified heterocyclic scaffolds.

1 Introduction

2 Type I Products: 1,4,5,6-Tetrahydropyridines

3 Type II Products: 1,2,3,4-Tetrahydropyridines

4 Type III Products: Bridged Perhydropyridines

5 Conclusion and Perspective

Supporting Information

 
  • References

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