Synthesis 2016; 48(09): 1389-1398
DOI: 10.1055/s-0035-1560416
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Quinazolines and Dihydroquinazolines: o-Iodoxybenzoic Acid Mediated Tandem Reaction of o-Aminobenzylamine with Aldehydes

Santanu Hati
Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Chithera, Dadri, Gautam Buddha Nagar, Uttar Pradesh, 201314, India   Email: [email protected]
,
Subhabrata Sen*
Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Chithera, Dadri, Gautam Buddha Nagar, Uttar Pradesh, 201314, India   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 31 December 2015

Accepted after revision: 08 February 2016

Publication Date:
11 March 2016 (online)


Abstract

We have demonstrated a facile synthesis of diversely substituted quinazolines and 3,4-dihydroquinazolines through the o-iodoxybenzoic acid (IBX) mediated tandem reaction of readily available o-aminobenzylamine and aldehydes. The yield of the reactions generally ranged from 70% to 95%. This mild protocol provides an efficient strategy toward the synthesis of these classes of heterocycles.

Supporting Information

 
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