Synthesis 2015; 47(14): 2032-2037
DOI: 10.1055/s-0034-1380813
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© Georg Thieme Verlag Stuttgart · New York

Synthesis of an Intermediate of Nafoxidine via Nickel-Catalyzed Ketone Arylation

Enrico Marelli
a  EaStCHEM, School of Chemistry, University of St Andrews North Haugh, St Andrews, Fife, KY16 9ST, UK
,
José A. Fernández Salas
a  EaStCHEM, School of Chemistry, University of St Andrews North Haugh, St Andrews, Fife, KY16 9ST, UK
,
Steven P. Nolan*
a  EaStCHEM, School of Chemistry, University of St Andrews North Haugh, St Andrews, Fife, KY16 9ST, UK
b  Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 24 March 2015

Accepted after revision: 24 April 2015

Publication Date:
09 June 2015 (online)


Abstract

A nickel-catalyzed methodology for the α-arylation of ketones has been applied to the synthesis of an industrially relevant intermediate. The optimization of the reaction shows the important influence of subtle changes in reaction conditions, and leads to an improved procedure employing only a small excess of the substrate and a relatively low catalyst loading.

Supporting Information

 
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