Synthesis 2015; 47(16): 2385-2390
DOI: 10.1055/s-0034-1380719
special topic
© Georg Thieme Verlag Stuttgart · New York

Toward a Green Atom Economy: Development of a Sustainable Multicomponent Reaction

Silvia Garbarino
a  Bioorganic Chemistry Group, Department of Chemistry and Industrial Chemistry, University of Genova, Via Dodecaneso 31, 16146 Genova, Italy   Email: andrea.basso@unige.it
,
Stefano Protti*
b  PhotoGreen Lab, Department of Chemistry University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy   Email: prottistefano@gmail.com
,
Andrea Basso*
a  Bioorganic Chemistry Group, Department of Chemistry and Industrial Chemistry, University of Genova, Via Dodecaneso 31, 16146 Genova, Italy   Email: andrea.basso@unige.it
› Author Affiliations
Further Information

Publication History

Received: 19 March 2015

Accepted after revision: 13 April 2015

Publication Date:
26 May 2015 (eFirst)

Abstract

The recently discovered photoinduced three-component reaction of diazo ketones, carboxylic acids, and isocyanides can be efficiently performed under continuous-flow conditions with consequential advantages in terms of selectivity and productivity. The investigation of the flow process and the determination of its sustainability are discussed in detail. This multicomponent reaction affords stereodefined captodative olefins, useful as synthons in organic chemistry.

 
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