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Synthesis 2015; 47(10): 1387-1389
DOI: 10.1055/s-0034-1380505
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© Georg Thieme Verlag Stuttgart · New York

A New and Practical Synthesis of Vortioxetine Hydrobromide

Yongjun Mao
,
Luobin Jiang
,
Tianyun Chen
,
Haijun He
,
Gang Liu
,
Han Wang*
Further Information

Publication History

Received: 25 January 2015

Accepted after revision: 05 March 2015

Publication Date:
13 April 2015 (online)

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Abstract

A new and improved synthetic route to vortioxetine hydrobromide is established on a hectogram scale through three simple steps in 63% yield and with 99% purity (HPLC). The key step is the cyclization of the piperazine ring in the final step. Purification methods for the intermediates involved in the route are given.

Key words

vortioxetine hydrobromide - new route - synthetic process - atypical antidepressant - green chemistry
 

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