Synthesis 2015; 47(19): 2971-2975
DOI: 10.1055/s-0034-1380222
special topic
© Georg Thieme Verlag Stuttgart · New York

An Iron-Catalyzed Direct Approach to Amides from Benzyl Azides via C–C Bond Cleavage

Yang Ou
a  State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Road 38, Beijing 100191, P. R. of China
,
Chong Qin
a  State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Road 38, Beijing 100191, P. R. of China
,
Song Song
a  State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Road 38, Beijing 100191, P. R. of China
,
Ning Jiao*
a  State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Road 38, Beijing 100191, P. R. of China
b  State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Ling Ling Rd. 345, Shanghai 200032, P. R. of China   Email: jiaoning@bjmu.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 12 May 2015

Accepted after revision: 05 June 2015

Publication Date:
06 August 2015 (eFirst)

Abstract

A novel iron-catalyzed transformation of benzyl azides to give the corresponding amides via C–C bond cleavage under mild reaction conditions is developed. This method provides a new synthetic tool for the construction of amides and the opportunity to accomplish C–C functionalization under mild conditions.

Supporting Information

 
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