Synthesis 2015; 47(01): 34-41
DOI: 10.1055/s-0034-1378931
psp
© Georg Thieme Verlag Stuttgart · New York

A Scalable, Chromatography-Free Synthesis of Benzotetramisole

David S. B. Daniels
a  School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK   Fax: +44(1334)463808   Email: [email protected]
,
Siobhan R. Smith
a  School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK   Fax: +44(1334)463808   Email: [email protected]
,
Tomas Lebl
a  School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK   Fax: +44(1334)463808   Email: [email protected]
,
Peter Shapland
b  GSK, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
,
Andrew D. Smith*
a  School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK   Fax: +44(1334)463808   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 22 August 2014

Accepted after revision: 17 October 2014

Publication Date:
21 November 2014 (online)


Abstract

The scalable, chromatography-free synthesis of the chiral isothiourea benzotetramisole (BTM) in two steps from commercially available materials is presented. A detailed procedure for the synthesis of both enantiomers and the racemate on ca. 10 gram scale is disclosed.

Supporting Information

 
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