Preparation of Functionalized Lithium, Magnesium, Aluminum, Zinc, Manganese­, and Indium Organometallics from Functionalized Organic Halides

Guillaume Dagousset; Cyril François; Thierry Leόn; Romain Blanc; Elodie Sansiaume-Dagousset; Paul Knochel

doi:10.1055/s-0034-1378672

Synthesis, Table of Contents

Synthesis 2014; 46(23): 3133-3171
DOI: 10.1055/s-0034-1378672

review

Preparation of Functionalized Lithium, Magnesium, Aluminum, Zinc, Manganese, and Indium Organometallics from Functionalized Organic Halides

Guillaume Dagousset

Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5‒13, 81377 Munich, Germany Phone: +49(89)218077680 Email: Paul.Knochel@cup.uni-muenchen.de

,

Cyril François

Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5‒13, 81377 Munich, Germany Phone: +49(89)218077680 Email: Paul.Knochel@cup.uni-muenchen.de

,

Thierry Leόn

Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5‒13, 81377 Munich, Germany Phone: +49(89)218077680 Email: Paul.Knochel@cup.uni-muenchen.de

,

Romain Blanc

Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5‒13, 81377 Munich, Germany Phone: +49(89)218077680 Email: Paul.Knochel@cup.uni-muenchen.de

,

Elodie Sansiaume-Dagousset

Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5‒13, 81377 Munich, Germany Phone: +49(89)218077680 Email: Paul.Knochel@cup.uni-muenchen.de

,

Paul Knochel*

Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5‒13, 81377 Munich, Germany Phone: +49(89)218077680 Email: Paul.Knochel@cup.uni-muenchen.de

› Author Affiliations

Abstract

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Abstract

An overview of the most significant synthetic methods currently available for the preparation of functionalized organometallic compounds starting from organic halides is presented and illustrated with recent applications.

1 Introduction

2 Metal Insertion

2.1 Magnesium

2.2 Aluminum

2.3 Zinc

2.4 Indium

2.5 Manganese

3 Halogen‒Metal Exchange

3.1 Lithium

3.2 Magnesium

3.3 Zinc

4 Conclusion

Key words

organometallic reagents - functional groups - organic halides - metal insertion - halogen‒metal exchange

Full Text

References

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Preparation of Functionalized Lithium, Magnesium, Aluminum, Zinc, Manganese­, and Indium Organometallics from Functionalized Organic Halides

Preparation of Functionalized Lithium, Magnesium, Aluminum, Zinc, Manganese, and Indium Organometallics from Functionalized Organic Halides