Thorac cardiovasc Surg 2014; 62(07): 605-611
DOI: 10.1055/s-0033-1360477
Original Thoracic
Georg Thieme Verlag KG Stuttgart · New York

The Outcome of Bifocal Surgical Resection in Non-Small Cell Lung Cancer with Synchronous Brain Metastases: Results of a Single Center Retrospective Study

Cabir Yuksel
1  Department of Thoracic Surgery, Faculty of Medicine, Ankara University, Ankara, Turkey
,
Melih Bozkurt
2  Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey
,
Bulent Mustafa Yenigun
1  Department of Thoracic Surgery, Faculty of Medicine, Ankara University, Ankara, Turkey
,
Serkan Enon
1  Department of Thoracic Surgery, Faculty of Medicine, Ankara University, Ankara, Turkey
,
Murat Ozkan
1  Department of Thoracic Surgery, Faculty of Medicine, Ankara University, Ankara, Turkey
,
S. Kenan Kose
3  Department of Biostatistic, Faculty of Medicine, Ankara University, Ankara, Turkey
,
Ayten Kayı Cangir
1  Department of Thoracic Surgery, Faculty of Medicine, Ankara University, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

07 August 2013

09 October 2013

Publication Date:
05 December 2013 (online)

Abstract

Background The reported median survival in patients with non-small cell lung cancer (NSCLC) metastases to the brain varies from 3 to 12 months with combined treatment modalities. Bifocal surgical resection of synchronous brain metastasis and primary NSCLC has not been reported widely, and there have been only a small number of articles published in the literature. The aim of this retrospective study was to evaluate the prognostic factors among patients undergoing bifocal surgical resection.

Materials and Methods We retrospectively analyzed 28 patients who had a solitary metastatic brain lesion at the time of diagnosis, and underwent synchronous surgical resection of the brain metastasis and primary lung tumor. Survival time was measured in all the patients from the date of craniotomy until death or the most recent date of follow-up for those still surviving.

Results Mean age was 53 years. The mean length of follow-up was 23.6 (4–69) months. The overall survival rates were 79, 42, and 8% at the 1st, 2nd, and 5th years, respectively. The median length of survival was 24 ± 3.8 months. The median survival was found to be statistically significantly lower for the stage T3 tumors when compared with both stage T1 and T2 tumors (p = 0.037).

Conclusion NSCLC patients with resectable solitary cranial metastasis, low locoregional stage (stages IA, IB, IIA) in which T3 status is counted out, with no mediastinal lymph node involvement or any other extrathoracic spread will mostly benefit from consecutive complete resection of both tumors and are supposed to have a better survival.