Synthesis 2014; 46(16): 2168-2174
DOI: 10.1055/s-0033-1341271
special topic
© Georg Thieme Verlag Stuttgart · New York

Direct Gold-Catalyzed Regioselective Tetrafunctionalization of Nonactivated Alkynes

Fang Wei
a  Key Lab for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. of China   Email: Xuzh@sdu.edu.cn
,
Xianghua Wang
a  Key Lab for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. of China   Email: Xuzh@sdu.edu.cn
,
Shasha Peng
a  Key Lab for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. of China   Email: Xuzh@sdu.edu.cn
,
Qiuhui Jia
a  Key Lab for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. of China   Email: Xuzh@sdu.edu.cn
,
Chao Jiang
a  Key Lab for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. of China   Email: Xuzh@sdu.edu.cn
,
Shili Liu
b  School of Medicine, Shandong University, Jinan 250012, P. R. of China
,
Zhenghu Xu*
a  Key Lab for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. of China   Email: Xuzh@sdu.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 27 February 2014

Accepted after revision: 13 April 2014

Publication Date:
12 May 2014 (eFirst)

Abstract

A simple and efficient method based on gold catalysis is reported for the synthesis of halogen-functionalized pyrrolidine ­aminals. A new alkyne tetrafunctionalization strategy is proposed for the first time.

Supporting Information

 
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