Synthesis 2014; 46(10): 1362-1366
DOI: 10.1055/s-0033-1341102
special topic
© Georg Thieme Verlag Stuttgart · New York

A Facile Route to H-Pyrazolo[5,1-a]isoquinolines through a Multicomponent Reaction of 2-Alkynylbenzaldehyde, Sulfonylhydrazine, and Benzyne

Jinming Yang
a  School of Pharmacy, Yancheng Teachers University, Yancheng, Jiangsu 224051, P. R. of China
,
Xingxin Yu
b  Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, P. R. of China
,
Jie Wu*
b  Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, P. R. of China
c  State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. of China   Fax: +86(21)65641740   Email: jie_wu@fudan.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 09 February 2014

Accepted after revision: 13 March 2014

Publication Date:
28 March 2014 (online)

Abstract

A facile and efficient route for the generation of H-pyrazolo[5,1-a]isoquinolines via a silver triflate catalyzed three-component reaction of 2-alkynylbenzaldehyde, tosylhydrazine, and benzyne is reported. This reaction proceeds smoothly under mild conditions with high efficiency.

Supporting Information

 
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