Synthesis 2014; 46(10): 1321-1328
DOI: 10.1055/s-0033-1341022
special topic
© Georg Thieme Verlag Stuttgart · New York

Synergistic Stereoselective Organocatalysis with Indium(III) Salts

Andrea Gualandi
a  Dipartimento di Chimica ‘G. Ciamician’, ALMA MATER STUDIORUM – Università di Bologna, Via Selmi 2, 40126 Bologna, Italy   Fax: +39(051)2099456   Email: piergiorgio.cozzi@unibo.it
,
Luca Mengozzi
a  Dipartimento di Chimica ‘G. Ciamician’, ALMA MATER STUDIORUM – Università di Bologna, Via Selmi 2, 40126 Bologna, Italy   Fax: +39(051)2099456   Email: piergiorgio.cozzi@unibo.it
,
Claire Margaret Wilson
b  Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Dublin, Ireland
,
Pier Giorgio Cozzi*
a  Dipartimento di Chimica ‘G. Ciamician’, ALMA MATER STUDIORUM – Università di Bologna, Via Selmi 2, 40126 Bologna, Italy   Fax: +39(051)2099456   Email: piergiorgio.cozzi@unibo.it
› Author Affiliations
Further Information

Publication History

Received: 14 January 2014

Accepted after revision: 25 February 2014

Publication Date:
25 March 2014 (eFirst)

Abstract

The compatibility of indium(III) Lewis acids with water and amines allows their employment in synergistic and cooperative catalysis. Stereoselective organocatalytic SN1-type reactions, in which carbenium ions are generated, are promoted by the presence of indium salts. The peculiar properties of indium salts can be exploited in organocatalysis for the design of water-compatible, benign, green processes. The development of such indium(III)-promoted organocatalytic procedures is the focus of our recent research, a summary of which is presented in this article.

Supporting Information

 
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