Nickel-Catalyzed Reductive Allylation of Ketones with Allylic Carbonates

Chenglong Zhao; Zhuozhen Tan; Zhuye Liang; Wei Deng; Hegui Gong

doi:10.1055/s-0033-1339111

Synthesis, Table of Contents

Synthesis 2014; 46(14): 1901-1907
DOI: 10.1055/s-0033-1339111

special topic

Nickel-Catalyzed Reductive Allylation of Ketones with Allylic Carbonates

Chenglong Zhao

^aDepartment of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, P. R. of China Fax: +86(21)66132410 Email: wdeng@shu.edu.cn Email: Hegui_gong@shu.edu.cn

,

Zhuozhen Tan

^aDepartment of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, P. R. of China Fax: +86(21)66132410 Email: wdeng@shu.edu.cn Email: Hegui_gong@shu.edu.cn

,

Zhuye Liang

^bCollege of Chemistry and Molecular Engineering, Zhengzhou University, 100 Science Road, Zhengzhou 450001, P. R. of China

,

Wei Deng*

^aDepartment of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, P. R. of China Fax: +86(21)66132410 Email: wdeng@shu.edu.cn Email: Hegui_gong@shu.edu.cn

,

Hegui Gong*

^aDepartment of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, P. R. of China Fax: +86(21)66132410 Email: wdeng@shu.edu.cn Email: Hegui_gong@shu.edu.cn

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Abstract

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Abstract

Nickel-catalyzed efficient umpolung allylation of ketones with allylic carbonates in the presence of zinc powder is developed, which accommodates a variety of allylic and ketone substrates. Although chiral ligand is necessary for the transformation, no enantioselectivity was observed.

Key words

nickel - catalysis - allylation - umpolung - ketones

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References

References

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