Tandem Regioselective Rhodium-Catalyzed Hydroformylation–Enantioselective Aminocatalytic anti-Mannich Reaction

Abstract

The first tandem regioselective hydroformylation and enantioselective organocatalytic anti-Mannich reaction is reported. Starting from α-olefins, valuable functionalized amino acid derivatives were obtained in excellent yields and with high levels of diastereo- and enantioselectivities. The products represent valuable building blocks for biologically and pharmaceutically interesting targets.

Key words

tandem reactions - asymmetric synthesis - homogeneous catalysis - organocatalysis - hydroformylation

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