Synthesis 2014; 46(10): 1311-1320
DOI: 10.1055/s-0033-1338602
special topic
© Georg Thieme Verlag Stuttgart · New York

Tandem Regioselective Rhodium-Catalyzed Hydroformylation–Enantioselective Aminocatalytic anti-Mannich Reaction

Sonja Diezel
Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, 79104 Freiburg i. Bg., Germany   Fax: +49(761)2038715   Email: bernhard.breit@chemie.uni-freiburg.de
,
Bernhard Breit*
Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, 79104 Freiburg i. Bg., Germany   Fax: +49(761)2038715   Email: bernhard.breit@chemie.uni-freiburg.de
› Author Affiliations
Further Information

Publication History

Received: 13 January 2014

Accepted: 08 February 2014

Publication Date:
26 March 2014 (online)

Abstract

The first tandem regioselective hydroformylation and enantioselective organocatalytic anti-Mannich reaction is reported. Starting from α-olefins, valuable functionalized amino acid derivatives were obtained in excellent yields and with high levels of diastereo- and enantioselectivities. The products represent valuable building blocks for biologically and pharmaceutically interesting targets.

Supporting Information

 
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