Synlett 2013; 24(7): 787-803
DOI: 10.1055/s-0032-1318326
account
© Georg Thieme Verlag Stuttgart · New York

Catalytic Ring Expansion Adventures

Jon T. Njardarson*
Department of Chemistry and Biochemistry, University of Arizona, 1306 E. University Blvd., Tucson, AZ 85721, USA
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received: 16. Januar 2013

Accepted after revision: 06. Februar 2013

Publikationsdatum:
11. März 2013 (online)


Preview

Abstract

This account summarizes the Njardarson group ring expansion journey from early vinyl oxirane explorations to the latest vinyl oxetane ring expansion discoveries. The evolution of the program and incredible success of Cu(hfacac)2 as catalyst is detailed. Application of these new ring expansion reactions to natural product, pharmaceutical and commodity chemical targets is discussed as well as our intriguing mechanistic journey and interesting entry into the world of chiral counterion catalysis.