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Synlett 2013; 24(7): 787-803
DOI: 10.1055/s-0032-1318326
DOI: 10.1055/s-0032-1318326
account
Catalytic Ring Expansion Adventures
Further Information
Publication History
Received: 16 January 2013
Accepted after revision: 06 February 2013
Publication Date:
11 March 2013 (online)
Abstract
This account summarizes the Njardarson group ring expansion journey from early vinyl oxirane explorations to the latest vinyl oxetane ring expansion discoveries. The evolution of the program and incredible success of Cu(hfacac)2 as catalyst is detailed. Application of these new ring expansion reactions to natural product, pharmaceutical and commodity chemical targets is discussed as well as our intriguing mechanistic journey and interesting entry into the world of chiral counterion catalysis.
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