Chiral Squaramide Catalyzed Asymmetric Conjugate Additions of 3-Substituted Oxindoles to Vinylphosphonates
Received: 25 January 2013
Accepted after revision: 20 March 2013
16 April 2013 (eFirst)
An efficient organocatalytic enantioselective conjugate addition of 3-substituted oxindoles to activated vinylphosphonates has been described. This reaction allows the facile synthesis of a new family of organophosphorus derivatives bearing an oxindole motif in high chemical yields with good to excellent stereoselectivities.