Palladium-Mediated Total Synthesis of Bioactive Natural Products

This review article is dedicated to my teacher Professor S. K. Talapatra of Calcutta University on the occasion of his 80^th birthday

Abstract

The search for efficient synthetic procedures for natural products, drugs, and materials with economical and ecological advantages is an important area of current interst in synthetic organic chemistry. We have made an attempt to summarize the progress made in this area since 2005. This article describes the syntheses of several natural products and drugs that employ multiple palladium-catalyzed processes in either a sequential or a domino fashion.

1 Introduction

2 Palladium-Mediated Synthesis of Alkaloids

2.1 Indole Alkaloids

2.2 Carbazole Alkaloids

2.3 Quinoline and Isoquinoline Alkaloids

2.4 Pyrrole and Pyridine Alkaloids

2.5 Pyrrolizidine and Indolizidine Alkaloids

2.6 Imidazole and Guanidine Alkaloids

2.7 Other Alkaloids

3 Palladium-Mediated Synthesis of Natural Products Containing a Sugar Moiety

4 Palladium-Mediated Synthesis of Marine Natural Products

5 Palladium-Mediated Synthesis of Amino Acids and Peptides

6 Palladium-Mediated Synthesis of Terpenoids

7 Miscellaneous Natural Products

8 Conclusion

Key words

palladium catalysis - natural product synthesis - biological activity - terpenoids - alkaloids - marine natural products - asymmetric allylic alkylation - C–H activation

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