Synthesis 2012; 44(10): 1521-1525
DOI: 10.1055/s-0031-1290806
special topic
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed Aerobic Oxidative Trifluoromethylation of H-Phospho­nates Using Trimethyl(trifluoromethyl)silane

Lingling Chu
a  Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. of China
,
Feng-Ling Qing*
a  Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. of China
b  College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, P. R. of China, Fax: +86(21)64166128   Email: flq@mail.sioc.ac.cn
› Author Affiliations
Further Information

Publication History

Received: 16 February 2012

Accepted after revision: 05 March 2012

Publication Date:
11 April 2012 (eFirst)

Abstract

Copper-catalyzed aerobic oxidative trifluoromethylation of readily accessible H-phosphonates was demonstrated for the first time. This method not only provides an alternative method for the facile synthesis of a series of biologically important CF3-phosphonates, but also demonstrates the first example of the efficient construction of a P–CF3 bond via transition-metal catalysis.

Supporting Information

 
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