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Synthesis 2012; 44(8): 1155-1158
DOI: 10.1055/s-0031-1290589
DOI: 10.1055/s-0031-1290589
special topic
Synthesis of 1-[(Triisopropylsilyl)ethynyl]-1λ3,2-benziodoxol-3(1H)-one and Alkynylation of Indoles, Thiophenes, and Anilines
Further Information
Publication History
Received: 19 January 2012
Accepted after revision: 24 February 2012
Publication Date:
22 March 2012 (online)
Abstract
An efficient procedure was developed for the synthesis of 1-[(triisopropylsilyl)ethynyl]-1λ3,2-benziodoxol-3(1H)-one on a 100-mmol (36-g) scale. The benziodoxolone can be used for the gold-catalyzed direct alkynylation of indole, 2-hexylthiophene, or N,N-dibenzylaniline on a 5- to 10-mmol scale.
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For reviews on direct alkynylation, see: