Design of New ‘DalPhos’ P,N-Ligands:
Applications in Transition-Metal Catalysis

Rylan J. Lundgren; Kevin D. Hesp; Mark Stradiotto

doi:10.1055/s-0030-1260321

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Synlett 2011(17): 2443-2458
DOI: 10.1055/s-0030-1260321

ACCOUNT

Design of New ‘DalPhos’ P,N-Ligands: Applications in Transition-Metal Catalysis

Rylan J. Lundgren, Kevin D. Hesp, Mark Stradiotto*
Department of Chemistry, Dalhousie University, Halifax, Nova Scotia B3H 4J3, Canada
Fax: +1(902)4941310; e-Mail: mark.stradiotto@dal.ca;

Further Information

Publication History

Received 1 June 2011
Publication Date:
19 September 2011 (online)

Abstract
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Abstract

This Account documents our recent progress toward the application of new P,N-ligands in transition-metal catalysis, including Ir-catalyzed ketone transfer hydrogenation, Pd-catalyzed cross-coupling of N-H containing substrates as well as acetone with aryl halides, and Au-catalyzed hydroamination of alkynes with dialkylamines.

1 Introduction

2 Ketone Transfer Hydrogenation

3 Pd-Catalyzed C-N Cross-Coupling and Acetone α-Arylation

3.1 Development of a Highly Versatile Catalyst System

3.2 Ammonia Monoarylation

3.3 Hydrazine Monoarylation

3.4 Acetone Monoarylation

4 Au-Catalyzed Hydroamination of Dialkylamines and Alkynes

5 Summary and Conclusions

Key words

cross-coupling - homogeneous catalysis - hydrogen transfer - palladium - amines

References and Notes

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50

DalPhos ligands including Mor-DalPhos are now commercially available.