Synthesis 2011(16): 2639-2643  
DOI: 10.1055/s-0030-1260119
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Ligand-Free Nickel-Catalyzed Conversion of Aldoximes into Nitriles

Yen-Ting Lia, Bei-Sih Liaoa, Hsin-Pei Chen*b, Shiuh-Tzung Liu*a
a Department of Chemistry, National Taiwan University, Taipei 106, Taiwan
Fax: +886(2)23636359; e-Mail: stliu@ntu.edu.tw;
b Department of Mechanical Engineering, Tungnan University, Shenkeng Dist., New Taipei City 222, Taiwan
Further Information

Publication History

Received 25 April 2011
Publication Date:
14 July 2011 (eFirst)

Abstract

Catalytic dehydration of aldoximes can be performed efficiently with NiCl2 in acetonitrile under neutral and mild conditions. Under these conditions, various functionalized aldoximes produce the corresponding nitriles in good to excellent yields.