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Synlett 2011(7): 974-978  
DOI: 10.1055/s-0030-1259731
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Catalyzed ortho-Arylation of N-Aryloxazolidinones with Simple Arenes Using Sodium Persulfate

Charles S. Yeung, Vy M. Dong*
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada
e-Mail: vdong@chem.utoronto.ca;
Further Information

Publication History

Received 15 October 2010
Publication Date:
15 March 2011 (online)

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Abstract

We report a Pd-catalyzed ortho-arylation of N-aryloxazolidinones under mild conditions. Our oxidative cross-coupling consumes sodium persulfate (Na2S2O8), a green and environmentally benign reagent, as the terminal oxidant. Trifluoroacetic acid (TFA) is critical for reactivity.

Key words

palladium - arylation - biaryl - cross-coupling - metallacycle

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