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Synlett 2011(7): 974-978
DOI: 10.1055/s-0030-1259731
DOI: 10.1055/s-0030-1259731
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New YorkPd-Catalyzed ortho-Arylation of N-Aryloxazolidinones with Simple Arenes Using Sodium Persulfate
Further Information
Received
15 October 2010
Publication Date:
15 March 2011 (online)
Publication History
Publication Date:
15 March 2011 (online)
Abstract
We report a Pd-catalyzed ortho-arylation of N-aryloxazolidinones under mild conditions. Our oxidative cross-coupling consumes sodium persulfate (Na2S2O8), a green and environmentally benign reagent, as the terminal oxidant. Trifluoroacetic acid (TFA) is critical for reactivity.
Key words
palladium - arylation - biaryl - cross-coupling - metallacycle
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