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Synfacts 2010(12): 1330-1330
DOI: 10.1055/s-0030-1258875
DOI: 10.1055/s-0030-1258875
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of (+)-Peloruside A
M. A. McGowan, C. P. Stevenson, M. A. Schiffler, E. N. Jacobsen*
Harvard University, Cambridge, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. November 2010 (online)
Significance
(+)-Peloruside A is a potent microtubule stabilizer isolated from a marine sponge in 2000. The first total synthesis was reported by De Brabander and co-workers (Angew. Chem. Int. Ed. 2003, 115, 1686). This synthesis of (+)-peloruside A was published back-to-back with a paper from Hoye and co-workers (see Synfacts 2010, 1331).