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Synthesis 2010(24): 4207-4212  
DOI: 10.1055/s-0030-1258311
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Iron/Palladium-Catalyzed Intramolecular Hydroamination: An Expedient Synthesis of Pyrrole-Annulated Coumarin and Quinolone Derivatives

K. C. Majumdar*, Nirupam De, B. Roy
Department of Chemistry, University of Kalyani, Kalyani 741235, W.B., India
Fax: +91(33)925828282; e-Mail: kcm_ku@yahoo.co.in;
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Publikationsverlauf

Received 30 August 2010
Publikationsdatum:
21. Oktober 2010 (online)

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Abstract

A highly efficient intramolecular hydroamination reaction of heterocycle-centered aminoalkynes using both substituted and free amines catalyzed by PdCl2/FeCl3 catalytic system to form the biologically important pyrrolocoumarin and pyrroloquinolone derivatives is reported. The use of both aliphatic and aromatic substituted alkynes with different heterocyclic skleton in this strategy demonstrated the diversity of this method.

Key words

hydroamination - pyrrolocoumarin - pyrroloquinolone - FeCl3 - aminoalkynes

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