Iron/Palladium-Catalyzed
Intramolecular Hydroamination: An Expedient Synthesis of Pyrrole-Annulated
Coumarin and Quinolone Derivatives

K. C. Majumdar; Nirupam De; B. Roy

doi:10.1055/s-0030-1258311

PAPER

Iron/Palladium-Catalyzed Intramolecular Hydroamination: An Expedient Synthesis of Pyrrole-Annulated Coumarin and Quinolone Derivatives

K. C. Majumdar*, Nirupam De, B. Roy
Department of Chemistry, University of Kalyani, Kalyani 741235, W.B., India
Fax: +91(33)925828282; e-Mail: kcm_ku@yahoo.co.in;

Abstract

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Abstract

A highly efficient intramolecular hydroamination reaction of heterocycle-centered aminoalkynes using both substituted and free amines catalyzed by PdCl₂/FeCl₃ catalytic system to form the biologically important pyrrolocoumarin and pyrroloquinolone derivatives is reported. The use of both aliphatic and aromatic substituted alkynes with different heterocyclic skleton in this strategy demonstrated the diversity of this method.

Key words

hydroamination - pyrrolocoumarin - pyrroloquinolone - FeCl₃ - aminoalkynes

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