Synlett 2010(4): 505-508  
DOI: 10.1055/s-0029-1219358
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B Antagonist

Zizheng Qian, Ian R. Baxendale, Steven V. Ley*Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
Fax: +44(1223)336442; e-Mail: svl1000@cam.ac.uk;
Further Information

Publication History

Received 6 January 2010
Publication Date:
08 February 2010 (eFirst)

Abstract

This article describes the continuous flow synthesis of ­6-methoxy-8-(4-methyl-1,4-diazepan-1-yl)-N-(4-morpholinophen-yl)-4-oxo-1,4-dihydroquinoline-2-carboxamide, a potent 5HT1B antagonist developed by AstraZeneca.