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Synlett
DOI: 10.1055/a-2735-9451
Letter
Published as part of the Special Issue dedicated to Prof. S. Chandrasekaran on his 80th birthday

Biomimetic Total Synthesis of Homodimeric Diels–Alder Adduct Thamnosin

Autoren

  • Dattatraya H. Dethe

    1   Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, India

  • Balu Dherange

    1   Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, India

Gefördert durch: Science and Engineering Research Board (SERB) CRG/2022/002967
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Graphical Abstract

Dedication

This manuscript is dedicated to Prof. S. Chandrasekaran on his 80th birthday.

Abstract

Thamnosin is a homodimeric Diels–Alder adduct. Model studies revealed that, with fine-tuning of the reaction conditions, two different modes of diene dimerization could be achieved. This strategy was successfully applied to the total synthesis of thamnosin.

Keywords

Homodimeric Diels–Alder - Dimerization - Biomimetic synthesis - Antifungal agents - Antimalarial

Supplementary Material



Publikationsverlauf

Eingereicht: 08. September 2025

Angenommen nach Revision: 17. Oktober 2025

Artikel online veröffentlicht:
21. November 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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