A Photochemical Cyclization of Glyoxalates via an Internally Directed C–H Insertion

Abstract

An unusual photochemical cyclization of glyoxylate esters has been described resulting in selective formation of an eight-membered lactone. Site-selective hydrogen abstraction leads to a novel C–H remote functionalization.

Keywords

Photolysis - C–H insertion - Glyoxylate - Cyclizations - Remote functionalization - Internally directed reactions

Publication History

Received: 10 September 2025

Accepted after revision: 16 October 2025

Article published online:
17 November 2025

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