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Synthesis
DOI: 10.1055/a-2722-7141
Paper

Streamlined Synthesis of Bulky (Dispersion Energy Donor) Iodobenzenes

Authors

  • Michael Fuhrmann

    1   Institute of Organic Chemistry, Justus Liebig University Giessen, Giessen, Germany (Ringgold ID: RIN9175)

  • Nils F Hacket

    1   Institute of Organic Chemistry, Justus Liebig University Giessen, Giessen, Germany (Ringgold ID: RIN9175)

  • Peter Richard Schreiner 

    1   Institute of Organic Chemistry, Justus Liebig University Giessen, Giessen, Germany (Ringgold ID: RIN9175)

Gefördert durch: Deutsche Forschungsgemeinschaft SCHR 597/41-1,SPP 2363
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We report an efficient synthesis of meta-substituted iodobenzenes from readily available starting materials. Negishi coupling utilizing Knochel’s protocol followed by iodination provides the desired compounds in excellent yields over two steps from readily available precursors. These iodobenzenes equipped with dispersion energy donors (DEDs) serve as building blocks for catalysts as demonstrated in the Corey-Bakshi-Shibata (CBS) reduction.



Publikationsverlauf

Eingereicht: 31. August 2025

Angenommen nach Revision: 13. Oktober 2025

Accepted Manuscript online:
13. Oktober 2025

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