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DOI: 10.1055/a-2722-7141
Streamlined Synthesis of Bulky (Dispersion Energy Donor) Iodobenzenes
Autoren
Funding Information This work was supported by the Deutsche Forschungsgemeinschaft (SPP 2363, SCHR 597/41-1).
Dedicated
Dedicated to Prof. Paul Knochel on the occasion of his 70th birthday
Abstract
We report an efficient synthesis of meta-substituted iodobenzenes from readily available starting materials. Negishi coupling utilizing Knochel’s protocol followed by iodination provides the desired compounds in excellent yields over two steps from readily available precursors. These iodobenzenes equipped with dispersion energy donors serve as building blocks for catalysts as demonstrated in the Corey–Bakshi–Shibata reduction.
Publikationsverlauf
Eingereicht: 31. August 2025
Angenommen nach Revision: 13. Oktober 2025
Accepted Manuscript online:
13. Oktober 2025
Artikel online veröffentlicht:
14. November 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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