Phosphine-Catalyzed Asymmetric [3+2] Cyclization of Oxetane MBH Carbonates and Thioaurones

Abstract

We have successfully applied 3-oxetanone-derived MBH carbonates in the phosphine-catalyzed asymmetric [3+2] cyclization with activated thioaurones. With l-threonine-derived amide phosphine as the catalyst, a series of oxetane bis-spiro cyclopentene skeletons, involving two spiral scaffold with vicinal tertiary and quaternary stereocenters, were constructed in good yield with good enantioselectivity and moderate to good diastereoselectivity.

Keywords

Oxetane - Phosphine - Asymmetric - [3+2] cyclization - Thioaurones - Bis-spiro

Publikationsverlauf

Eingereicht: 16. Juli 2025

Angenommen nach Revision: 08. Oktober 2025

Accepted Manuscript online:
08. Oktober 2025

Artikel online veröffentlicht:
04. November 2025

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