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Synthesis
DOI: 10.1055/a-2718-6602
Paper

Phosphine Catalyzed Asymmetric [3+2] Cyclization of Oxetane MBH Carbonates and Thioaurones

Authors

  • Shuo Ding

    1   School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, China (Ringgold ID: RIN12646)

  • Xiao Han

    1   School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, China (Ringgold ID: RIN12646)

  • Zhen Wang

    2   School of Pharmaceutical Sciences, Chongqing University, Chongqing, China (Ringgold ID: RIN47913)

  • Weijun Yao 

    3   Chemistry, Zhejiang Sci-Tech University, Hangzhou, China (Ringgold ID: RIN12646)

Supported by: Natural Science Foundation of Zhejiang Province LTZ22B020002
Supported by: Natural Science Foundation of Chongqing cstc2020jcyj-msxmX0720
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We have successfully applied 3-oxetanone derived MBH carbonates in the phosphine catalyzed asymmetric [3+2] cyclization with activated thioaurones. With L-threonine derived amide phosphine as the catalyst, a series of oxetane bis-spiro cyclopentene skeletons, involving two spiral scaffold with vicinal tertiary and quaternary stereocenters, were constructed in good yield with good enantioselectivity and moderate to good distereoselectivity.Key words oxetane,



Publication History

Received: 16 July 2025

Accepted after revision: 08 October 2025

Accepted Manuscript online:
08 October 2025

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