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DOI: 10.1055/a-2705-9526
Research on the Synthetic Methodology for Lurasidone Hydrochloride
Authors
This study was supported by Scientific Research Projects (Natural Sciences) of Higher Education Institutions in Anhui Province (No. 2023AH051821 and No. 2023AH051805), Anhui Provincial University Students’ Innovation and Entrepreneurship Training Program (No. S202312216123) and Anhui Provincial Education Department’s Quality Engineering Program (No.2022sx061).
Supported by: Scientific Research Projects (Natural Sciences) of Higher Education Institutions in Anhui Province 2023AH051805,2023AH051821
Supported by: Anhui Provincial Education Department’s Quality Engineering Program 2022sx061
Abstract
In this study, the antipsychotic drug ruprasidone hydrochloride was synthesized using (1R,2R)-1,2-cyclohexanedimethanol as the starting material. The synthesis process was carried out through four steps: sulfonylation, N-alkylation, substitution, and acidification with hydrochloric acid. Eventually, lurasidone hydrochloride was obtained with a total yield of 34.3%, calculated based on (1R,2R)-1,2-cyclohexanedimethanol. The structure of the target compound was confirmed by 1H NMR and 13C NMR spectroscopic analyses. The reported synthetic process offers several advantages of high yield, simple steps, high cost-effectiveness and safe operation, and the synthetic process is suitable for industrial production. This study provides a methodological reference for the industrial manufacturing of ruprasidone hydrochloride.
Publication History
Received: 31 July 2025
Accepted after revision: 27 August 2025
Accepted Manuscript online:
19 September 2025
Article published online:
18 November 2025
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