Synthetic Studies on Lolium Alkaloids

Dedication

Dedicated to Professor Paul Knochel on the occasion of his 70th birthday.

Abstract

We report the first total synthesis of several natural products of the loline family, including the unusual chloropyrrolizidine alkaloid lolidine. We demonstrate the utility of an azide intermediate in our synthesis toward click-chemistry and late-stage functionalization. Lastly, we further explore the CO₂ absorbing properties of temuline, as well as a potential application of loline as a chiral ligand in palladium chemistry.

Keywords

Lolidine - Loline - Temuline - Alkaloid - Total synthesis - Click-chemistry - CO₂ absorption

Publikationsverlauf

Eingereicht: 31. August 2025

Angenommen nach Revision: 18. September 2025

Accepted Manuscript online:
18. September 2025

Artikel online veröffentlicht:
31. Oktober 2025

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